The most common form of Robertsonian translocations is between chromosomes 13 and 14, which accounts for approximately 75% of all translocations. The translocation can thus be passed through several generations without detection. ![]() ![]() Many carriers never learn about their chromosomal rearrangement since carriers typically exhibit no negative health consequences or reduced life span. The individual who has a balanced translocation is referred to as a Robertsonian translocation carrier. It results from the breakage of two acrocentric chromosomes at or close to their centromeres, with a subsequent fusion of the long arms to form one metacentric chromosome. A Robertsonian translocation involves only the acrocentric chromosomes (13, 14, 15, 21, and 22). ![]() One in 1,000 healthy individuals is thought to carry a Robertsonian translocation inherited from one of the parents with a normal phenotype. Robertsonian (rob) translocation is the most common form of structural chromosomal abnormality or rearrangement.
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